Clarksburg may refer to some places in the United States of America:
- Clarksburg, California
- Clarksburg AVA, an American Viticultural Area
- Clarksburg, former name of Clarksville, California
- Clarksburg, Indiana
- Clarksburg, Maryland
- Clarksburg, Massachusetts
- Clarksburg, Michigan
- Clarksburg, Missouri
- Clarksburg, New Jersey
- Clarksburg, Ohio
- Clarksburg, Pennsylvania
- Clarksburg, Tennessee
- Clarksburg, West Virginia