Clarice Starling - Hannibal

In Hannibal, Starling is in her early thirties and a full-fledged FBI agent, although her career has been held back by a vengeful superior, Paul Krendler, at the Department of Justice. She takes part in a bungled drug raid, in which she returns fire after a drug kingpin fires at her, using an infant as a hostage; her superiors blame her for the resulting mess, and she is removed from active duty, mostly at Krendler's instigation. She receives a supportive letter from Lecter, who is (unknown to her at the time) residing in Florence, Italy. One of Lecter's surviving victims, a sadistic pedophile named Mason Verger, is searching for Lecter and has offered a huge reward, which a corrupt Florentine police inspector named Pazzi tries to claim when he deduces Lecter's true identity in Florence.

Starling finds out that Lecter is in Florence and attempts to warn Pazzi. As Starling predicted, Lecter knows about the plot to capture him and, as a result, he kills Pazzi. Lecter then flees to the United States and immediately starts to follow Starling. Starling, meanwhile, is being harassed at the FBI by various corrupt agents, especially by Krendler, who is secretly assisting Verger in his attempt to capture Lecter. Starling attempts to find Lecter first, not only to capture him but also to save him from Verger. Krendler attempts to frame Starling in a scheme planned by Verger, alleging she sent coded newspaper messages to Lecter; this only results in her being suspended, but she is now powerless to stop Verger's men. Lecter is captured by Verger, who plans to feed him to a pack of specially bred wild boars.

Starling is aware that Lecter is being held by Verger, so she attempts to save him. She is wounded in the ensuing gunfight; Lecter rescues her and nurses her back to health. He then subjects her to a regimen of mind-altering drugs and classical conditioning in an attempt to make her believe she is his long-dead sister, Mischa.

During this time, Lecter captures Krendler and performs a craniotomy on him while he is still alive. During an elaborate dinner, Lecter scoops spoonfuls of Krendler's forebrain to saute with lemon and capers. In the novel, he feeds Krendler's brain to Starling, who finds it delicious.

Lecter's plan to brainwash Starling ultimately fails, as she refuses to have her own personality sublimated. Then, in the novel's most controversial sequence, she opens her dress and offers her breast to Lecter; he accepts her offer and the two became lovers. They disappear together, only to be sighted again three years later entering the Teatro Colón opera house in Buenos Aires by former orderly Barney Matthews, who had befriended and respected Lecter while he was incarcerated in Baltimore. Fearing for his life, Barney leaves Buenos Aires immediately, never to return.