Cissy may refer to:
- Cissy (Pokémon), a character from the Pokémon anime show
- Narcissa Malfoy, nicknamed 'Cissy', from the Harry Potter stories
- Cissy Chandler wife of Raymond Thornton Chandler, an American author of crime stories and novels.
- Cissy Houston born Emily Drinkard, an American soul and gospel singer.
- Cissie Caudeiron born Mabel Alice Caudeiron, a Creole nationalist and folklorist from Roseau, Dominica.
- Cissy Gool, a South African politician and anti-apartheid leader.
- Cissy King born Claire Yvonne King, an American-born singer and dancer best known as a featured performer on The Lawrence Welk Show.
- Cissi Klein born Cissi Pera Klein, a Norwegian Jewish girl who is commemorated every year as one of the victims of the Holocaust.
- Cissie and Ada, a British television skit from the 1970s and 1980s.
- Cissie Loftus a Scottish actress, singer, mimic, vaudevillian and music hall performer in the late 19th and early 20th centuries.
- Cissy Patterson US writer, newspaper publisher, owner, editor, countess, socialite &c.
- Cissie Stewart Sarah Gillow Marshall "Cissie" Stewart a British swimmer who competed in the 1928 Summer Olympics.