CISA may refer to:
- Education, diplomas
- Cambridge International Studies Association, a student Society at Cambridge University
- Centre for Intelligent Systems and their Applications, School of Informatics, University of Edinburgh
- Certified Information Systems Auditor, a professional certification for information technology audit professionals sponsored by ISACA
- Council of International Students Australia, peak representative body for international students studying in Australia
- Business
- China Iron and Steel Association
- Costruzioni Italiane Serrature e Affini, an Italian brand of locking and access control systems
- Media
- CISA-DT, the Global Television Network station in Lethbridge, Alberta
- Research
- Swiss Center for Affective Sciences in Geneva
- Religions, history
- A potential alternate spelling of the name of the Germanic goddess Zisa (goddess)