Similar Genes Can Result in A Range of Different Diseases
"Just as different genes can contribute to similar diseases, so the same genes and families of genes can play a part in a range of different diseases." For example, in just two of the diseases caused by malfunctioning cilia, Meckel-Gruber syndrome and Bardet-Biedl syndrome, patients who carry mutations in genes associated with both diseases "have unique symptoms that are not seen in either condition alone." The genes linked to the two different conditions "interact with each other during development." Systems biologists are endeavoring to define functional modules containing multiple genes and then look at disorders whose phenotypes fit into such modules.
A particular phenotype can overlap "considerably with several conditions (ciliopathies) in which primary cilia are also implicated in pathogenicity. One emerging aspect is the wide spectrum of ciliopathy gene mutations found within different diseases."
Read more about this topic: Ciliopathy
Famous quotes containing the words similar, genes, result, range and/or diseases:
“The history of all Magazines shows plainly that those which have attained celebrity were indebted for it to articles similar in natureto Berenice—although, I grant you, far superior in style and execution. I say similar in nature. You ask me in what does this nature consist? In the ludicrous heightened into the grotesque: the fearful coloured into the horrible: the witty exaggerated into the burlesque: the singular wrought out into the strange and mystical.”
—Edgar Allan Poe (1809–1849)
“Whether you want it or not,
your genes have a political past,
your skin a political tone.
your eyes a political color.
...
you walk with political steps
on political ground.”
—Wislawa Szymborska (b. 1923)
“The contention that a standing army and navy is the best security of peace is about as logical as the claim that the most peaceful citizen is he who goes about heavily armed. The experience of every-day life fully proves that the armed individual is invariably anxious to try his strength. The same is historically true of governments. Really peaceful countries do not waste life and energy in war preparations, with the result that peace is maintained.”
—Emma Goldman (1869–1940)
“Jane Addams, founder of Hull House, once asked, “How shall we respond to the dreams of youth?” It is a dazzling and elegant question, a question that demands an answer—a range of answers, really, spiraling outward in widening circles.”
—William Ayers, U.S. author. To Teach: The Journey of a Teacher, ch. 7 (1993)
“A fiction about soft or easy deaths ... is part of the mythology of most diseases that are not considered shameful or demeaning.”
—Susan Sontag (b. 1933)