Chthon may refer to:
- Chthon (comics), two separate fictional entities from Marvel Comics and DC Comics
- Chthon (novel), a 1967 science fiction novel by Piers Anthony
Chthon may also refer to:
- Chthonian (Cthulhu Mythos), a fictional race, created by Brian Lumley
- Chthonian planet, a type of planet
- Chthonic, a term in Greek mythology
- Chthonic (band), a Taiwanese black metal band
- Chthon (Quake), A boss in the computer game Quake
- The House of Chthon is a major vampire house in Blade: The Series