Lithium
Exposure to lithium has also been used as a method to induce chromatolysis in rats. The study involved the injection of large does of lithium chloride into female Lewis rats over several day periods. Examination of the trigeminal and dorsal root ganglia revealed peripheral chromatolysis in these cells. The cells exhibited decreased numbers of Nissl bodies throughout the cell, especially at the peripheral cytoplasm were the Nissl bodies were completely absent. Using lithium as a method to induce peripheral chromatolysis could be useful for future study of chromatolysis due to its simplicity and the fact it does not cause nuclear displacement.
Read more about this topic: Chromatolysis, Causes