Chromatolysis - Associated Diseases - Alcoholic Encephalopathy

Alcoholic Encephalopathy

Chromatolysis has been reported in patients with alcoholic encephalopathies. Central chromatolysis was observed mainly among neurons in the brainstem, particularly in the pontine nuclei and the cerebellar dentate nuclei. Nuclei of cranial nerves, arcuate nuclei, and posterior horn cells were also affected. Studies examining patients with alcoholic encephalopathies give evidence of central chromatolysis. Mild to severe degeneration of spinal cord tracks has been observed in patients with Marchiafava-Bignami disease and Wernicke-Korsakoff syndrome, both forms of encephalopathy linked to alcohol.

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