Chimeric Antigen Receptor
Artificial T cell receptors (also known as chimeric T cell receptors, chimeric immunoreceptors, chimeric antigen receptors (CARs)) are engineered receptors, which graft an arbitrary specificity onto an immune effector cell. Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T cell; with transfer of their coding sequence facilitated by retroviral vectors. In this way, a large number of cancer-specific T cells can be generated for adoptive cell transfer. Phase I clinical studies of this approach show efficacy.
Read more about Chimeric Antigen Receptor: Anatomy of Chimeric Antigen Receptors, Evolution of CAR T-cell Design, History of Chimeric Antigen Receptors, Clinical Studies Testing Chimeric Antigen Receptor, Improving The Safety of Adoptive Transfer CAR-modified Cells As A Cancer Therapeutic
Famous quotes containing the word receptor:
“The disinterest [of my two great-aunts] in anything that had to do with high society was such that their sense of hearing ... put to rest its receptor organs and allowed them to suffer the true beginnings of atrophy.”
—Marcel Proust (1871–1922)