CHI3L1

CHI3L1

Identifiers Symbols CHI3L1; ASRT7; CGP-39; GP-39; GP39; HC-gp39; HCGP-3P; YKL-40; YKL40; YYL-40; hCGP-39 External IDs OMIM: 601525 MGI: 1340899 HomoloGene: 55569 GeneCards: CHI3L1 Gene

Gene Ontology
Molecular function	• chitinase activity • extracellular matrix structural constituent • chitin binding • cation binding
Cellular component	• proteinaceous extracellular matrix • extracellular space • cytoplasm • endoplasmic reticulum
Biological process	• carbohydrate metabolic process • chitin catabolic process • inflammatory response • activation of NF-kappaB-inducing kinase activity • response to mechanical stimulus • positive regulation of peptidyl-threonine phosphorylation • lung development • response to tumor necrosis factor • positive regulation of angiogenesis • cartilage development • positive regulation of protein kinase B signaling cascade • positive regulation of ERK1 and ERK2 cascade • response to interleukin-1 • response to interleukin-6 • cellular response to interleukin-1 • cellular response to tumor necrosis factor • interleukin-8 secretion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1116 12654 Ensembl ENSG00000133048 ENSMUSG00000064246 UniProt P36222 Q61362 RefSeq (mRNA) NM_001276 NM_007695 RefSeq (protein) NP_001267 NP_031721 Location (UCSC) Chr 1:
203.15 – 203.16 Mb Chr 1:
134.18 – 134.19 Mb PubMed search

Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and it's molecular mass. YKL-40 is secreted by various cell-types including macrophages, chondrocytes, and some types of cancer cells. YKL-40 lacks chitinase activity due to mutations within the active site (conserved sequence: DXXDXDXE ; YKL-40 sequence: DGLDLAWL). The exact physiological role of YKL-40 is not known, but it has been implicated in development, inflammatory disease (such as asthma, and cancer progression).