Charles Spencer-Churchill may refer to:
- Lord Charles Spencer-Churchill (British Army officer) (1794–1840), was a British nobleman
- Charles Henry Spencer-Churchill (1828-1877), British officer and diplomat and a British consul in Ottoman Syria
- Charles Spencer-Churchill, 9th Duke of Marlborough (1871-1934)
- Jamie Spencer-Churchill, Marquess of Blandford (born 1955), full name Charles James Spencer-Churchill, son of the 11th Duke of Marlborough