Charles W. Mayser was an American football and baseball coach in the United States. He served three stints as the head football coach at Franklin & Marshall College (1913–1914, 1924–1925, 1944–1945) and was the head football coach at Iowa State University from 1915 to 1919, compiling a career college football record of 46–32–5. Mayser was also the head baseball coach at Iowa State for two seasons, from 1919 to 1920, tallying a mark of 18–8–1.