Charles Lawrence may refer to:
- Charles Lawrence (British Army officer) (1709–1760), British Army officer and Governor of Nova Scotia, 1756–1760
- Charles Lawrence (cricketer) (1828–1916), Anglo-Australian cricketer
- Charles Frederick Lawrence (1873–1940), English antiquarian
- Charles S. Lawrence (1892–1970), United States army colonel
- Charles Lawrence, 1st Baron Lawrence of Kingsgate (1855–1927), Chairman of the London and North Western Railway
- Charles Lawrence (mathematician), American bioinformatician and mathematician
- Charles Drummond Lawrence (1878–1975), judge for the United States Customs Court