Charles IV may refer to:
- Charles IV of France, "the Fair" (1294–1328)
- Charles IV, Holy Roman Emperor (1316–1378)
- Charles IV of Navarre (1421–1461)
- Charles IV, Duke of Anjou (1436–1481)
- Charles IV of Alençon (1489–1525)
- Charles V, Holy Roman Emperor and IV of Naples (1500–1558)
- Charles IV, Duke of Lorraine (1604–1675)
- Charles Emmanuel IV of Sardinia (1751–1802), styled "Charles IV of England and Scotland" by Jacobites
- Charles IV of Spain (1748–1819)
- Charles IV of Norway (1826–1872)
- Charles IV of Hungary (1887–1922)