Charles de Bourbon may refer to:
- Charles I, Duke of Bourbon (1401–1456)
- Charles II, Duke of Bourbon (1434–1488), also Cardinal and archbishop of Lyon
- Charles III, Duke of Bourbon (1490–1527), Bourbon-Montpensier
- Charles de Bourbon, Duke of Vendôme (1489–1537), Bourbon-La Marche
- Charles, Cardinal de Bourbon (1523–1590), Bourbon-La Marche, archbishop of Rouen and also Cardinal
- Charles de Bourbon, Archbishop of Rouen (1564–1610)
- Charles de Bourbon, comte de Soissons (1566–1612), Bourbon-Soissons
- Charles de Bourbon, Duc de Berry (1686–1714)
- Charles III of Spain, known as Charles of Bourbon (1716 – 1788), King of Spain, Naples, and Sicily