Charles or Charlie Cox may refer to:
- Charles E. Cox (1860–1936), Indiana Supreme Court judge
- Charles Frederick Cox (1863–1944), Australian soldier
- Charles Winnans Cox (1882–1958), Canadian politician
- Charlie Cox (born 1982), English actor
- Charlie Cox (footballer born 1905) (1905–1978), English footballer
- Charlie Cox (footballer born 1926) (1926–2008), Scottish footballer
- Charlie Cox (racing driver) (born 1960), Australia motor racing commentator
- Sir Charles Cox (brewer) (1660–1729), English brewer and MP
- Charles Chapman Cox, US SEC Commissioner and economist
- Charles Christopher Cox (born 1952), US politician and financial regulator