Charles Biddle (1745–1821) was a Pennsylvania statesman.
His father was William Biddle, 3rd (1698–1756), and mother was Mary Scull (1709–1789). He served as Vice-President of Pennsylvania from October 10, 1785 until October 31, 1787. During his term, he was an ex officio trustee of the University of the State of Pennsylvania (now the University of Pennsylvania). He was a member of the Pennsylvania Senate from 1810 to 1814. He also was an associate of Aaron Burr.
Although Biddle vacated his seat at Council on October 13, 1787 the Commonwealth of Pennsylvania records that his Vice-Presidential term extended to October 31, the date of the next Presidential and Vice-Presidential elections. Biddle was elected Secretary of the Council on October 23.
He was married to Hannah Shephard and had 10 children, including James, Nicholas, Thomas, John and Richard.