Baron Charles-Ferdinand N.M.P. Nothomb (born 3 May 1936 in Brussels) is a French speaking Belgian politician.
He is a member of the Humanist Democratic Centre (cdH). He served as Belgian Minister of Foreign Affairs from 1980 until 1981. Since 2002 Nothomb has been Vice President of the European Movement international.
Charles-Ferdinand Nothomb is the great-uncle of the Belgian writer Amélie Nothomb.