Disulfide Bridges
The disulfide bridge between Cys42-Cys58 forms part of the fibrinogen recognition subsite S’ that is recognized as crucial for thrombin’s ability to hydrolyze alpha- and beta-chains. Mutations within the S’ site have shown a decrease in the thrombin-facilitated fibrinogenolysis. However, the lack of a Cys, and therefore disulfide bridge in that region, in cerastocytin has no effect on fibrin clot formation or platelet aggregation.
Read more about this topic: Cerastocytin, Structural Comparison To Thrombin
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“... this single span,
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