Structural Comparison To Thrombin
Cerastocytin, like most other serine proteases, thrombin specifically, has three distinguishing features: the hydrophobic pocket, the positive surface and the catalytic triad. Additionally, the tertiary structure of cerastocytin is maintained by disulfide bridges similar to those formed in other serine proteases. This structural similarity results of cerastocytin’s ability to clot platelets and hydrolyze fibrinogen at the concentration of 5 nM, closely mimics the activity of thrombin at 1nM.
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