Cerastocytin - Comparison To Some Other Venom Proteases

Comparison To Some Other Venom Proteases

Cerastotin is a more potent platelet proaggregant than cerastocytin because at a given amount it is just as active as an equal amount of crude venom. Pure cerastocytin, on the other hand, induces platelet aggregation six times slower than an equivalent volume of venom. However, while cerastotin is more f kinetically avoredthan cerastocytin, it can only bind platelets in the presence of fibrinogen. Furthermore, its receptor binding site is not the same as that of thrombin. This is confirmed by the fact that cerastotin was still active after a thrombin desensitization test and was not affected by the competitive inhibitors of thrombin.