Clinical Implications
Dysfunction of cell-adhesion and cell-migration occurs during cancer metastasis. Cellular adhesion and traction can allow cells to migrate. Cells can form intergrin mediated attachments sites called focal adhesions. Focal adhesions at the leading edge provide the necessary traction allowing the cell to pull itself forward.
Pemphigus is the result of auto-antibodies which target desmosomal cadherins. Results in loss of cell adhesion.
Read more about this topic: Cell Adhesion
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