CDKN1B

CDKN1B

Identifiers Symbols CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27KIP1 External IDs OMIM: 600778 MGI: 104565 HomoloGene: 2999 GeneCards: CDKN1B Gene

Gene Ontology
Molecular function	• cyclin-dependent protein kinase inhibitor activity • transforming growth factor beta receptor, cytoplasmic mediator activity • protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • protein phosphatase binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • endosome • cytosol
Biological process	• cell cycle checkpoint • regulation of cyclin-dependent protein kinase activity • G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • mitotic cell cycle • potassium ion transport • induction of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cell cycle arrest • epidermal growth factor receptor signaling pathway • sensory perception of sound • positive regulation of cell proliferation • negative regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • positive regulation of cell death • negative regulation of cell growth • positive regulation of microtubule polymerization • negative regulation of kinase activity • negative regulation of phosphorylation • negative regulation of apoptotic process • positive regulation of protein catabolic process • negative regulation of cyclin-dependent protein kinase activity • negative regulation of transcription, DNA-dependent • negative regulation of mitotic cell cycle • nerve growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • autophagic cell death • inner ear development • negative regulation of cellular component movement • negative regulation of epithelial cell proliferation involved in prostate gland development • cellular response to antibiotic • cellular response to lithium ion • cellular response to organic cyclic compound • mitotic cell cycle arrest
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1027 12576 Ensembl ENSG00000111276 ENSMUSG00000003031 UniProt P46527 P46414 RefSeq (mRNA) NM_004064 NM_009875 RefSeq (protein) NP_004055 NP_034005 Location (UCSC) Chr 12:
12.87 – 12.88 Mb Chr 6:
134.92 – 134.93 Mb PubMed search

Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.