CDC42

CDC42

Identifiers Symbols CDC42; CDC42Hs; G25K External IDs OMIM: 116952 MGI: 106211 HomoloGene: 123986 ChEMBL: 6088 GeneCards: CDC42 Gene

Gene Ontology
Molecular function	• GTPase activity • protein binding • GTP binding • protein kinase binding • GTP-dependent protein binding • mitogen-activated protein kinase kinase kinase binding • thioesterase binding • apolipoprotein A-I receptor binding • identical protein binding
Cellular component	• Golgi membrane • cytoplasm • microtubule organizing center • cytosol • plasma membrane • secretory granule • filopodium • midbody • neuron projection • neuronal cell body • apical part of cell • spindle midzone • mitotic spindle
Biological process	• cardiac conduction system development • keratinocyte development • GTP catabolic process • Golgi organization • regulation of mitosis • nuclear migration • establishment or maintenance of cell polarity • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • axon guidance • blood coagulation • positive regulation of gene expression • negative regulation of gene expression • actin cytoskeleton organization • macrophage differentiation • hair follicle morphogenesis • positive regulation of pseudopodium assembly • T cell costimulation • negative regulation of protein complex assembly • keratinization • regulation of protein stability • positive regulation of peptidyl-serine phosphorylation • adherens junction organization • cellular protein localization • establishment or maintenance of apical/basal cell polarity • multicellular organism growth • negative regulation of epidermal growth factor receptor signaling pathway • regulation of protein catabolic process • muscle cell differentiation • regulation of protein heterodimerization activity • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of DNA replication • regulation of protein kinase activity • positive regulation of JNK cascade • filopodium assembly • neuron fate determination • actin filament bundle assembly • regulation of small GTPase mediated signal transduction • positive regulation of muscle cell differentiation • regulation of filopodium assembly • establishment of Golgi localization • regulation of attachment of spindle microtubules to kinetochore • heart contraction • canonical Wnt receptor signaling pathway • epithelial-mesenchymal cell signaling • hair follicle placode formation • positive regulation of hair follicle cell proliferation • positive regulation of cell cycle cytokinesis • organelle transport along microtubule • epithelial cell-cell adhesion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 998 12540 Ensembl ENSG00000070831 ENSMUSG00000006699 UniProt P60953 P60766 RefSeq (mRNA) NM_001039802.1 NM_001243769.1 RefSeq (protein) NP_001034891.1 NP_001230698.1 Location (UCSC) Chr 1:
22.38 – 22.42 Mb Chr 4:
137.32 – 137.36 Mb PubMed search

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.