Function of Cdc25 in Activating Cdk1
Cdc25 activates cyclin dependent kinases by the removal of phosphates from residues in the Cdk active site. Also, the phosphorylation of M-Cdk (a complex of Cdk1 and cyclin B) activates Cdc25. Together with Wee1, M-Cdk activation is switch-like. The switch-like behavior forces entry into mitosis to be quick and irreversible. Cdk activity can be reactivated after phosphorylation by Cdc25. The Cdc25 enzymes Cdc25A-C are known to control the transitions from G1 to S phase and G2 to M phase.
Read more about this topic: CDC25A
Famous quotes containing the words function of, function and/or activating:
“Think of the tools in a tool-box: there is a hammer, pliers, a saw, a screwdriver, a rule, a glue-pot, nails and screws.—The function of words are as diverse as the functions of these objects.”
—Ludwig Wittgenstein (1889–1951)
“Literature does not exist in a vacuum. Writers as such have a definite social function exactly proportional to their ability as writers. This is their main use.”
—Ezra Pound (1885–1972)
“it is best then that the buried word remain buried for we were intended to appreciate only its fruits and not the secret principle activating them to know this would be to know too much. Meanwhile it is possible to know just enough, and this is all we were supposed to know, toward which we have been straining all our lives.”
—John Ashbery (b. 1927)