CDC20

CDC20

Identifiers Symbols CDC20; CDC20A; bA276H19.3; p55CDC External IDs OMIM: 603618 MGI: 1859866 HomoloGene: 37459 GeneCards: CDC20 Gene

Gene Ontology
Molecular function	• protein binding • protein C-terminus binding • enzyme binding
Cellular component	• spindle pole • nucleoplasm • anaphase-promoting complex • centrosome • spindle • cytosol • perinuclear region of cytoplasm
Biological process	• cell cycle checkpoint • M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • cell cycle • mitotic cell cycle spindle assembly checkpoint • positive regulation of cell proliferation • protein ubiquitination • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • positive regulation of synaptic plasticity • regulation of meiosis • regulation of dendrite development • cell division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • activation of anaphase-promoting complex activity • positive regulation of synapse maturation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 991 107995 Ensembl ENSG00000117399 ENSMUSG00000006398 UniProt Q12834 Q9JJ66 RefSeq (mRNA) NM_001255 NM_023223 RefSeq (protein) NP_001246 NP_075712 Location (UCSC) Chr 1:
43.82 – 43.83 Mb Chr 4:
118.43 – 118.44 Mb PubMed search

The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APCCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

CDC20 appears to act as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes: nuclear movement prior to anaphase, and chromosome separation.