CDC16

CDC16

Identifiers Symbols CDC16; ANAPC6; APC6; CUT9 External IDs OMIM: 603461 MGI: 1917207 HomoloGene: 2899 GeneCards: CDC16 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleoplasm • anaphase-promoting complex • cytoplasm • centrosome • spindle • cytosol • spindle microtubule
Biological process	• cell cycle checkpoint • mitotic cell cycle • mitosis • regulation of mitosis • mitotic cell cycle spindle assembly checkpoint • cell proliferation • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cell division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein K11-linked ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8881 69957 Ensembl ENSG00000130177 ENSMUSG00000038416 UniProt Q13042 Q3TI84 RefSeq (mRNA) NM_001078645 NM_027276 RefSeq (protein) NP_001072113 NP_081552 Location (UCSC) Chr 13:
115 – 115.04 Mb Chr 8:
13.76 – 13.78 Mb PubMed search

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.