Regulation
In S. cerevisiae, Cdc14 is regulated by its competitive inhibitor Cfi/Net1, which localizes Cdc14 to the nucleolus. During anaphase, Cdc14 is "uncaged" and spreads to the rest of the cell. Two networks mediate the release of Cdc14 from the nucleolus: FEAR (CDC Fourteen Early Anaphase Release) and MEN (Mitotic Exit Network); while these networks are complex, it is thought that these networks result in the phosphorylation of Cfi/Net1 and/or Cdc14, resulting in disassociation of the complex. In S. pombe, phosphorylation of the Cdc14 ortholog by Cdk1 is known to directly inhibit the catalytic activity of the phosphatase.
Read more about this topic: CDC14
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