Expression
It is expressed on all leukocytes but highest on thymocytes and is believed to augment T-cell adhesion, apoptosis of double positive t cells, and participates in migration and activation. There is also experimental evidence that it binds to cyclophilin A.
It is positive in Ewing's sarcoma and granulosa cell tumors. Antibodies to CD99 are used in diagnostic immunohistochemistry to distinguish Ewing's sarcoma from other tumours of similar histological appearance, as well as for the identification of thymic tumours, and of spindle cell tumours, such as synovial sarcoma, haemangiopericytoma, and meningioma.
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