Use in Stem Cell Biology
Thy-1 can be considered as a surrogate marker for various kind of stem cells (e.g. hematopoietic stem cells or HSCs). It is one of the popular combinatorial surface markers for FACS for stem cells in combination with other markers like CD34. During sorting, mouse HSCs fall under Thy1hi subpopulation, while human HSCs fall under the Thy1lo subpopulation. In humans, Thy-1 is expressed on neurons and HSCs among others. It is considered a major marker of HSC pluripotency in concordance with CD34. In human HSCs, Thy1 cells are all CD34 positive.Thy 1 is also a marker of other kind of stem cells, for example: mesenchymal stem cells, hepatic stem cells ("oval cells"), keratinocyte stem cells, putative endometrial progenitor/(?)stem cells.
Read more about this topic: CD90
Famous quotes containing the words stem, cell and/or biology:
“Apples? New Hampshire has them, but unsprayed,
With no suspicion in stem end or blossom end
Of vitriol or arsenate of lead,
And so not good for anything but cider.”
—Robert Frost (1874–1963)
“It is plain that there is no separate essence called courage, no cup or cell in the brain, no vessel in the heart containing drops or atoms that make or give this virtue; but it is the right or healthy state of every man, when he is free to do that which is constitutional to him to do.”
—Ralph Waldo Emerson (1803–1882)
“The “control of nature” is a phrase conceived in arrogance, born of the Neanderthal age of biology and the convenience of man.”
—Rachel Carson (1907–1964)