CD90 - Use in Stem Cell Biology

Use in Stem Cell Biology

Thy-1 can be considered as a surrogate marker for various kind of stem cells (e.g. hematopoietic stem cells or HSCs). It is one of the popular combinatorial surface markers for FACS for stem cells in combination with other markers like CD34. During sorting, mouse HSCs fall under Thy1hi subpopulation, while human HSCs fall under the Thy1lo subpopulation. In humans, Thy-1 is expressed on neurons and HSCs among others. It is considered a major marker of HSC pluripotency in concordance with CD34. In human HSCs, Thy1 cells are all CD34 positive.Thy 1 is also a marker of other kind of stem cells, for example: mesenchymal stem cells, hepatic stem cells ("oval cells"), keratinocyte stem cells, putative endometrial progenitor/(?)stem cells.

Read more about this topic:  CD90

Famous quotes containing the words stem, cell and/or biology:

    Ignorance, the root and stem of all evil.
    Plato (c. 427–347 B.C.)

    There’s not one part of his physical being that’s like that of human beings. From his warped brain down to the tiniest argumentative cell of his huge carcass, he’s unearthly.
    —Willis Cooper. Rowland V. Lee. Wolf von Frankenstein (Basil Rathbone)

    The “control of nature” is a phrase conceived in arrogance, born of the Neanderthal age of biology and the convenience of man.
    Rachel Carson (1907–1964)