CD61

CD61

Identifiers Symbols ITGB3; BDPLT2; CD61; GP3A; GPIIIa; GT External IDs OMIM: 173470 MGI: 96612 HomoloGene: 55444 ChEMBL: 207 GeneCards: ITGB3 Gene

Gene Ontology
Molecular function	• protein disulfide isomerase activity • receptor activity • platelet-derived growth factor receptor binding • protein binding • identical protein binding • vascular endothelial growth factor receptor 2 binding • cell adhesion molecule binding
Cellular component	• plasma membrane • integral to plasma membrane • integrin complex • platelet alpha granule membrane • melanosome • alphav-beta3 integrin-vitronectin complex
Biological process	• positive regulation of protein phosphorylation • positive regulation of endothelial cell proliferation • platelet degranulation • protein folding • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • axon guidance • blood coagulation • positive regulation of endothelial cell migration • negative regulation of macrophage derived foam cell differentiation • negative regulation of lipid storage • smooth muscle cell migration • virus-host interaction • platelet activation • positive regulation of vascular endothelial growth factor receptor signaling pathway • activation of protein kinase activity • negative regulation of lipid transport • tube development • wound healing • regulation of bone resorption • negative regulation of low-density lipoprotein particle receptor biosynthetic process • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of lipoprotein metabolic process • leukocyte migration • angiogenesis involved in wound healing • platelet aggregation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3690 16416 Ensembl ENSG00000259207 ENSMUSG00000020689 UniProt P05106 O54890 RefSeq (mRNA) NM_000212.2 NM_016780.2 RefSeq (protein) NP_000203.2 NP_058060.2 Location (UCSC) Chr 17:
45.33 – 45.42 Mb Chr 11:
104.61 – 104.67 Mb PubMed search

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.