CD59

Identifiers Symbols CD59; 16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20 External IDs OMIM: 107271 MGI: 1888996 HomoloGene: 56386 GeneCards: CD59 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• extracellular region • plasma membrane • cell surface • membrane • anchored to external side of plasma membrane
Biological process	• cell surface receptor signaling pathway • blood coagulation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 966 333883 Ensembl ENSG00000085063 ENSMUSG00000068686 UniProt P13987 P58019 RefSeq (mRNA) NM_000611.5 NM_181858.1 RefSeq (protein) NP_000602.1 NP_862906.1 Location (UCSC) Chr 11:
33.72 – 33.76 Mb Chr 2:
104.07 – 104.09 Mb PubMed search

CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin is a protein that in humans is encoded by the CD59 gene.

CD59 inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. It is present on "self" cells to prevent complement from damaging them. CD59, along with CD55 are not present in the condition paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.