CD40 (protein)

CD40 (protein)

Identifiers Symbols CD40; Bp50; CDW40; TNFRSF5; p50 External IDs OMIM: 109535 MGI: 88336 HomoloGene: 954 ChEMBL: 1250358 GeneCards: CD40 Gene

Gene Ontology
Molecular function	• signal transducer activity • receptor activity • protein binding • enzyme binding • ubiquitin protein ligase binding
Cellular component	• extracellular region • plasma membrane • integral to plasma membrane • external side of plasma membrane • CD40 receptor complex • intracellular membrane-bounded organelle
Biological process	• positive regulation of protein phosphorylation • immune response-regulating cell surface receptor signaling pathway • protein complex assembly • cellular calcium ion homeostasis • inflammatory response • platelet activation • positive regulation of B cell proliferation • positive regulation of interleukin-12 production • positive regulation of Rac GTPase activity • B cell proliferation • positive regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of Cdc42 GTPase activity • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of MAP kinase activity • positive regulation of transcription from RNA polymerase II promoter • positive regulation of isotype switching to IgG isotypes • regulation of immune response • regulation of immunoglobulin secretion • positive regulation of NF-kappaB transcription factor activity • defense response to virus • cellular response to mechanical stimulus • positive regulation of protein kinase C signaling cascade • positive regulation of endothelial cell apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 958 21939 Ensembl ENSG00000101017 ENSMUSG00000017652 UniProt P25942 P27512 RefSeq (mRNA) NM_001250.4 NM_011611.2 RefSeq (protein) NP_001241.1 NP_035741.2 Location (UCSC) Chr 20:
44.75 – 44.76 Mb Chr 2:
165.06 – 165.07 Mb PubMed search

CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on T_H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

Deficiency can cause Hyper-IgM syndrome type 3.