CD4
| Gene Ontology | |
|---|---|
| Molecular function | • glycoprotein binding • receptor activity • transmembrane signaling receptor activity • extracellular matrix structural constituent • protein binding • zinc ion binding • coreceptor activity • enzyme binding • protein kinase binding • MHC class II protein binding • protein homodimerization activity |
| Cellular component | • early endosome • endoplasmic reticulum lumen • endoplasmic reticulum membrane • plasma membrane • external side of plasma membrane • integral to membrane • T cell receptor complex • membrane raft |
| Biological process | • cytokine production • induction by virus of host cell-cell fusion • immune response • cell adhesion • signal transduction • cell surface receptor signaling pathway • enzyme linked receptor protein signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • viral reproduction • T cell differentiation • entry into host cell • T cell costimulation • maintenance of protein location in cell • T cell selection • positive regulation of interleukin-2 biosynthetic process • innate immune response • protein palmitoleylation • positive regulation of protein kinase activity • regulation of defense response to virus by virus • positive regulation of peptidyl-tyrosine phosphorylation • defense response to Gram-negative bacterium • positive regulation of calcium-mediated signaling • T cell receptor signaling pathway • regulation of T cell activation |
| Sources: Amigo / QuickGO | |
6.9 – 6.93 Mb
124.86 – 124.89 Mb
| CD4, extracellular | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| structure of t-cell surface glycoprotein cd4, monoclinic crystal form | |||||||||
| Identifiers | |||||||||
| Symbol | CD4-extracel | ||||||||
| Pfam | PF09191 | ||||||||
| InterPro | IPR015274 | ||||||||
| SCOP | 1cid | ||||||||
| SUPERFAMILY | 1cid | ||||||||
| OPM superfamily | 230 | ||||||||
| OPM protein | 2klu | ||||||||
| CDD | cd07695 | ||||||||
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. Read more about CD4: Structure, Function | |||||||||