Clinical Significance
CD20 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias.
The anti-CD20 mAB Ofatumumab (Genmab) was approved by FDA in Oct 2009 for Chronic lymphocytic leukemia.
Additional anti-CD20 antibody therapeutics under development (phase II or III clinical trials in 2008) include :
- AME-133v (by Applied Molecular Evolution),
- Ocrelizumab for multiple sclerosis (rheumatoid arthritis discontinued in 2010),
- TRU-015 (by Trubion), (discontinued in 2010)
- IMMU-106 (veltuzumab).
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