CD20

CD20

Identifiers Symbols MS4A1; B1; Bp35; CD20; CVID5; LEU-16; MS4A2; S7 External IDs OMIM: 112210 MGI: 88321 HomoloGene: 7259 ChEMBL: 2058 GeneCards: MS4A1 Gene

Gene Ontology
Molecular function	• epidermal growth factor receptor binding
Cellular component	• nucleolus • plasma membrane • integral to plasma membrane • external side of plasma membrane
Biological process	• immune response • B cell activation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 931 12482 Ensembl ENSG00000156738 ENSMUSG00000024673 UniProt P11836 P19437 RefSeq (mRNA) NM_021950.3 NM_007641.5 RefSeq (protein) NP_068769.2 NP_031667.1 Location (UCSC) Chr 11:
60.22 – 60.24 Mb Chr 19:
11.25 – 11.27 Mb PubMed search

B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity.

In humans CD20 is encoded by the MS4A1 gene.

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants that encode the same protein.