CD135

CD135

Identifiers Symbols FLT3; CD135; FLK-2; FLK2; STK1 External IDs OMIM: 136351 MGI: 95559 HomoloGene: 3040 ChEMBL: 1974 GeneCards: FLT3 Gene EC number 2.7.10.1

Gene Ontology
Molecular function	• transmembrane receptor protein tyrosine kinase activity • cytokine receptor activity • vascular endothelial growth factor-activated receptor activity • protein binding • ATP binding • protein homodimerization activity • phosphatidylinositol 3-kinase binding
Cellular component	• endoplasmic reticulum lumen • integral to plasma membrane • cell surface
Biological process	• leukocyte homeostasis • myeloid progenitor cell differentiation • pro-B cell differentiation • pro-T cell differentiation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell proliferation • negative regulation of cell proliferation • positive regulation of phosphatidylinositol 3-kinase cascade • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • hemopoiesis • B cell differentiation • common myeloid progenitor cell proliferation • vascular endothelial growth factor signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • regulation of apoptotic process • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • negative regulation of B cell differentiation • lymphocyte proliferation • protein autophosphorylation • cellular response to cytokine stimulus • dendritic cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2322 14255 Ensembl ENSG00000122025 ENSMUSG00000042817 UniProt P36888 Q00342 RefSeq (mRNA) NM_004119.2 NM_010229.2 RefSeq (protein) NP_004110.2 NP_034359.2 Location (UCSC) Chr 13:
28.58 – 28.67 Mb Chr 5:
147.33 – 147.4 Mb PubMed search

Cluster of differentiation antigen 135 (CD135) also known as Fms-like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. Flt3 is a cytokine receptor which belongs to the receptor tryrosin kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (Flt3L).

It is expressed on the surface of many hematopoietic progenitor cells. Signalling of Flt3 is important for the normal development of haematopoietic stem cells and progenitor cells.

The FLT3 gene is one of the most frequently mutated genes in acute myeloid leukemia (AML). Besides, high levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. These high levels may be associated with worse prognosis.