| Gene Ontology | |
|---|---|
| Molecular function | • metal ion binding • protein heterodimerization activity • cell adhesion molecule binding |
| Cellular component | • immunological synapse • plasma membrane • integrin complex • external side of plasma membrane |
| Biological process | • T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • cellular component movement • inflammatory response • cell adhesion • heterophilic cell-cell adhesion • leukocyte cell-cell adhesion • signal transduction • integrin-mediated signaling pathway • blood coagulation • positive regulation of cell-cell adhesion • positive regulation of T cell proliferation • regulation of immune response • activated T cell proliferation • positive regulation of calcium-mediated signaling • leukocyte migration |
| Sources: Amigo / QuickGO | |
30.48 – 30.53 Mb
127.3 – 127.34 Mb
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.
CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.
Efalizumab acts as an immunosuppressant by binding to CD11a.