CCS (gene)

CCS (gene)

Identifiers Symbols CCS; MGC138260 External IDs OMIM: 603864 MGI: 1333783 HomoloGene: 3762 GeneCards: CCS Gene

Gene Ontology
Molecular function	• superoxide dismutase activity • copper ion transmembrane transporter activity • copper ion binding • protein binding • zinc ion binding • superoxide dismutase copper chaperone activity • enzyme binding
Cellular component	• nucleus • cytoplasm • mitochondrial inner membrane • cytosol
Biological process	• superoxide metabolic process • intracellular copper ion transport • removal of superoxide radicals • copper ion transmembrane transport • positive regulation of oxidoreductase activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9973 12460 Ensembl ENSG00000173992 ENSMUSG00000034108 UniProt O14618 Q543K2 RefSeq (mRNA) NM_005125 NM_016892 RefSeq (protein) NP_005116 NP_058588 Location (UCSC) Chr 11:
66.36 – 66.37 Mb Chr 19:
4.83 – 4.84 Mb PubMed search

Copper chaperone for superoxide dismutase is a metalloprotein that in humans is encoded by the CCS gene.

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.