CCR1

CCR1

Identifiers Symbols CCR1; CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1 External IDs OMIM: 601159 MGI: 104618 HomoloGene: 20344 IUPHAR: CCR1 ChEMBL: 2413 GeneCards: CCR1 Gene

Gene Ontology
Molecular function	• phosphatidylinositol phospholipase C activity • chemokine receptor activity • protein binding • C-C chemokine receptor activity • C-C chemokine binding • chemokine (C-C motif) ligand 7 binding • chemokine (C-C motif) ligand 5 binding
Cellular component	• plasma membrane • integral to plasma membrane • external side of plasma membrane
Biological process	• dendritic cell chemotaxis • calcium ion transport • cellular calcium ion homeostasis • exocytosis • chemotaxis • inflammatory response • immune response • cell adhesion • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • elevation of cytosolic calcium ion concentration • cell-cell signaling • response to wounding • negative regulation of gene expression • cytokine-mediated signaling pathway • negative regulation of bone mineralization • positive regulation of osteoclast differentiation • positive regulation of calcium ion transport • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of monocyte chemotaxis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1230 12768 Ensembl ENSG00000163823 ENSMUSG00000025804 UniProt P32246 P51675 RefSeq (mRNA) NM_001295 NM_009912 RefSeq (protein) NP_001286 NP_034042 Location (UCSC) Chr 3:
46.24 – 46.25 Mb Chr 9:
123.96 – 123.97 Mb PubMed search

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.