Structure and Expression
The caveolins are similar in structure. They all form hairpin loops that are inserted into the cell membrane. Both the C-terminus and the N-terminus face the cytoplasmic side of the membrane. There are two isoforms of caveolin-1: caveolin-1α and caveolin-1β, the latter lacking a part of the N-terminus.
Caveolins are found in the majority of adherent, mammalian cells.
- Caveolin-1 is most prominently expressed in endothelial, fibrous and adipose tissue.
- The expression pattern of caveolin-2 is similar to that of caveolin-1; it seems to be co-expressed with caveolin-1.
- The expression of caveolin-3 is restricted to striated and smooth muscle.
Read more about this topic: Caveolin
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