Cats & Dogs: The Revenge of Kitty Galore - Plot

Plot

At a satellite base in Northern Germany, a worker named Freidrich (Fred Armisen), delivering secret codes finds a Cocker Spaniel puppy outside his office but the dog turns out to be Kitty Galore (voiced by Bette Midler), an evil female hairless Sphynx cat, in disguise. Freidrich's bloodhound Rex turns out to be a dog agent and reports to HQ.

In San Francisco, Diggs (voiced by James Marsden), a German Shepherd police dog is suspended from the force after blowing up a car dealership. Butch, an Anatolian Shepherd, (voiced by Nick Nolte) and Lou (voiced by Neil Patrick Harris), the head of D.O.G. HQ, recruit him to D.O.G. HQ. to stop Kitty Galore from broadcasting "The Call of the Wild", a sound that will drive dogs all around the world completely insane. After tracking down a pigeon named Seamus with valuable information, Diggs and Butch meet a M.E.O.W.S. (Mousers Enforcing Our World's Safety) agent named Catherine (voiced by Christina Applegate) who was after Seamus for the same reason the dogs were. After bringing Catherine to HQ, Lou and Tab Lazenby (voiced by Roger Moore), the head of M.E.O.W.S, form an alliance to take down Kitty Galore much to Diggs's dismay. Diggs was jealous of Catherine for having better gadgets while he got nothing. At a cat lady's home, they discover the middlecat who has been sending parts of stolen technology to kitty using other pigeons that work for her, but claims that he does not know where she is hiding. Diggs ruined the plan when he disobey orders almost causing them to be killed kitty litter.

After talking to Mr Tinkles (voiced by Sean Hayes) who is locked up in Alcatraz, two mercenaries named Angus and Duncan MacDougall (voiced by Michael Beattie and Jeff Bennett respectively) attempt to assassinate Seamus on the boat returning from the prison. Diggs subdues Angus and accidentally throws him overboard. After getting fed up with Diggs ruining the mission, Butch votes him off the team and leaves with Seamus. Catherine takes Diggs to her home, where she learns that the reason why Diggs never follows orders is because he never trust anyone but himself, which lead to him getting into the kennels a lot. She tells Diggs if he continues doing these bad habits, no one will able to help him. With that said, Diggs realizes how stupid he has been and Catherine takes Diggs to M.E.O.W.S. HQ, where they learn that Kitty is hiding at a fairground with her new master, an amateur magician named Chuck the Magnificent (Jack McBrayer). Not long after arriving at the fairground, Diggs and Catherine are captured by Kitty Galore and her henchcat, Paws. Butch and Seamus are alerted of Diggs and Catherine's capture. Kitty reveals to Diggs and Catherine that she plots to transmit "The Call of the Wild" via an orbiting satellite which only dogs can hear through televisions, radios and cellphones to cause them to act hostile towards their humans. They will then be left alone and unwanted in kennels. Diggs and Catherine however escape and meet up with Butch and Seamus. Kitty uses the roof of the fairground's flying swings ride for a satellite dish. Diggs, Butch, Catherine and Seamus arrive. Seamus presses a red button, thinking it is a shutdown button, but it instead loads the "Call of the Wild" signal. Dogs around the world start acting insane in their homes. Paws battles them, revealing he is a robot in the process. Diggs tricks Paws into biting the wires, destroying the satellite. Kitty's pet mouse, Scrumptious, fed up with Kitty's abuse towards him, fires her away. Kitty lands in the magician's hat with the humans thinking it was a stunt, while Diggs and the others escape.

After the mission, Diggs goes to live with Shane before coming to H.Q. to learn that Mr Tinkles has escaped from prison with the middlecat (aka Calico) and hacked their systems, so Diggs, Butch, Seamus, and Catherine go to stop him.