CASY Cell Counting Technology - Differences Between CASY and Coulter Cell Counting

Differences Between CASY and Coulter Cell Counting

A Coulter counter is one of the other devices used for cell counting. Like CASY technology, this also uses electric current for cell counting. However, the difference between them is that there is an aperture called “sensing zone”, with a known volume of electrolyte in a coulter counter. When suspended cells pass through it, they would displace the equivalent volume of electrolyte in the sensing zone and cause a short term change of electric current across the aperture. Since the circuit is to detect the change of current across it, any particles that can displace the electrolyte will be counted. It would be seen that the measurement of cells would be from a volume to another volume in the same sample.

In contrast, the CASY technology incorporates no electrolytic reservoir in the aperture and the cells in the electrolyte can pass through the measuring pore. It would be not necessary to detect the cells from a batch to another batch but measure them continuously and smoothly.

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