Casadesus is the surname of a prominent French musical family. Its members include:
- Francis Casadesus (1870–1954), composer and conductor
- Robert-Guillaume Casadesus (1878–1940), composer and singer known as "Robert Casa"
- Henri Casadesus (1879–1947), violist
- Marcel Casadesus (1882–1914), cellist
- Marius Casadesus (1892–1981), violinist and composer
- Robert Casadesus (1899–1972), pianist
- Gaby Casadesus (1901–1999), pianist
- Mathilde Casadesus (1921–1965), actress
- Jean Casadesus (1927–1972), pianist
- Jean-Claude Casadesus (born 1935), conductor