Caruana may refer to:
- Alfonso Caruana (born 1946), member of the Sicilian Mafia
- Anthony Caruana (born 1968), Melbourne, Australia based technology journalist
- Antonio Annetto Caruana (1830–1905), Maltese archaeologist and author
- Charles Caruana CBE (1932–2010), Roman Catholic Bishop of Gibraltar
- Christian Caruana (born 1986), Maltese international footballer who plays as a midfielder
- Cuntrera-Caruana Mafia clan, part of the Sicilian Mafia or Cosa Nostra
- Fabiano Caruana (born 1992), the youngest ever chess grandmaster of both the United States and Italy
- Gabriel Caruana (born 1929), Maltese artist who works primarily in ceramics
- George Caruana (1831–1872), Maltese minor philosopher mostly interested in epistemology
- Jaime Caruana (born 1952), currently working at the BIS
- John Caruana (1866–1923), Maltese lawyer and minor philosopher
- Jonathan Caruana (born 1986), professional footballer playing as a defender
- Laurence Caruana (born 1962), Maltese artist, writer and lecturer
- Lydia Caruana, Maltese operatic soprano
- Matt Caruana (born 1985), Canadian professional ice hockey player
- Patrick P. Caruana (born 1939), retired Lieutenant General in the United States Air Force
- Peter Caruana QC (born 1956), Gibraltarian politician and Chief Minister of Gibraltar
- Raymond Caruana, Maltese Nationalist Party activist, murdered in 1986
- Vinnie Caruana (born 1979), American singer
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