Cardinal of Guise can refer to these members of the French ducal family de Guise who became cardinals:
- Louis I, Cardinal of Guise (1527-1578), Bishop of Troyes, 1545, created cardinal by Pope Julius III on December 22, 1553. He received the archbishopric of Sens on May 9, 1561, but resigned it in 1562 to Cardinal de Pellevée. On October 5, 1568, he was made Bishop of Metz. He crowned Henry III of France at Reims, (February 13, 1575).
- Louis II, Cardinal of Guise, (1555-1588), nephew of Louis I, Probably the more common usage.
- Louis III, Cardinal of Guise, (1575–1621), the third son of Henry I, Duke of Guise and Catherine of Cleves.
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