Cardiac Action Potential - Major Currents

Major Currents

Major currents during the cardiac ventricular action potential
Ion Current (I) α subunit protein α subunit gene Phase / role
Na+ INa NaV1.5 SCN5A 0
Ca2+ ICa(L) CaV1.2 CACNA1C 0-2
K+ Ito1 KV4.2/4.3 KCND2/KCND3 1, notch
K+ IKs KV7.1 KCNQ1 2,3
K+ IKr KV11.1 (hERG) KCNH2 3
K+ IK1 Kir2.1/2.2/2.3 KCNJ2/KCNJ12/KCNJ4 3,4
Na+, Ca2+ INaCa 3Na+-1Ca2+-exchanger NCX1 (SLC8A1) ion homeostasis
Na+, K+ INaK 3Na+-2K+-ATPase ATP1A ion homeostasis
Ca2+ IpCa Ca2+-transporting ATPase ATP1B ion homeostasis

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