Cardiac Action Potential - Major Currents

Major Currents

Major currents during the cardiac ventricular action potential
Ion Current (I) α subunit protein α subunit gene Phase / role
Na+ INa NaV1.5 SCN5A 0
Ca2+ ICa(L) CaV1.2 CACNA1C 0-2
K+ Ito1 KV4.2/4.3 KCND2/KCND3 1, notch
K+ IKs KV7.1 KCNQ1 2,3
K+ IKr KV11.1 (hERG) KCNH2 3
K+ IK1 Kir2.1/2.2/2.3 KCNJ2/KCNJ12/KCNJ4 3,4
Na+, Ca2+ INaCa 3Na+-1Ca2+-exchanger NCX1 (SLC8A1) ion homeostasis
Na+, K+ INaK 3Na+-2K+-ATPase ATP1A ion homeostasis
Ca2+ IpCa Ca2+-transporting ATPase ATP1B ion homeostasis

Read more about this topic:  Cardiac Action Potential

Famous quotes containing the words major and/or currents:

    “A dead martyr is just another corpse.”
    —Leo V. Gordon, U.S. screenwriter, and Arthur Hiller. Major Craig (Rock Hudson)

    “For it does not follow because many books are written by persons born in America that there exists an American literature. Books which imitate or represent the thoughts and life of Europe do not constitute an American literature. Before such can exist, an original idea must animate this nation and fresh currents of life must call into life fresh thoughts along its shores.”
    —Margaret Fuller (1810–1850)