CARD Domains in Apoptosis
CARD domains were originally characterized based on their involvement in the regulation of caspase activation and apoptosis. The basic six-helix structure of the domain appears to be conserved as far back as the ced-3 and ced-4 genes in C. elegans, the organism in which several components of the apoptotic machinery were first characterized. CARD motifs are present on a number of proteins that promote apoptosis, primarily caspases 1,2,4,5,9, and 15 in mammals.
Read more about this topic: CARD Domain
Famous quotes containing the words card and/or domains:
“What is the disease which manifests itself in an inability to leave a party—any party at all—until it is all over and the lights are being put out?... I suppose that part of this mania for staying is due to a fear that, if I go, something good will happen and I’ll miss it. Somebody might do card tricks, or shoot somebody else.”
—Robert Benchley (1889–1945)
“I shall be a benefactor if I conquer some realms from the night, if I report to the gazettes anything transpiring about us at that season worthy of their attention,—if I can show men that there is some beauty awake while they are asleep,—if I add to the domains of poetry.”
—Henry David Thoreau (1817–1862)