Structure
The CB1 receptor shares the structure characteristic of all G-protein-coupled receptors, possessing seven transmembrane domains connected by three extracellular and three intracellular loops, an extracellular N-terminal tail, and an intracellular C-terminal tail. These receptors may exist as homodimers or form heterodimers or oligomers when coexpressed with one or more classes of G-protein-coupled receptors. Observed heterodimers include A2ACB1, A2A, CB1D2, orexin 1/CB1, while many more may only be stable enough to exist in vivo. Recent evidence suggests that these receptors may also possess an allosteric binding site, which may become a target for enhancing the clinical modulatory effects of cannabinoids.
Read more about this topic: Cannabinoid Receptor Type 1
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—Paul Tillich (1886–1965)
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—Donald Davidson (b. 1917)