Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“Two wooden tubs of blue hydrangeas stand at the foot of the stone steps.
The sky is a blue gum streaked with rose. The trees are black.
The grackles crack their throats of bone in the smooth air.
Moisture and heat have swollen the garden into a slum of bloom.
Pardie! Summer is like a fat beast, sleepy in mildew....”
—Wallace Stevens (1879–1955)
“The wealth and prosperity of the country are only the comeliness of the body, the fullness of the flesh and fat; but the spirit is independent of them; it requires only muscle, bone and nerve for the true exercise of its functions. We cannot lose our liberty, because we cannot cease to think.”
—Humphry, Sir Davy (1778–1829)
“Sang a bone upon the shore;
“A child found all a child can lack,
Whether of pleasure or of rest,
Upon the abundance of my breast”:
A bone wave-whitened and dried in the wind.
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—William Butler Yeats (1865–1939)