Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“the bone dry voices of the peepers
as they throb like advertisements.”
—Anne Sexton (1928–1974)
“Fowls in the frith,
Fishes in the flood,
And I must wax wod:
Much sorrow I walk with
For best of bone and blood.”
—Unknown. Fowls in the Frith. . .
Oxford Book of Short Poems, The. P. J. Kavanagh and James Michie, eds. Oxford University Press.
“Sang a bone upon the shore;
“A child found all a child can lack,
Whether of pleasure or of rest,
Upon the abundance of my breast”:
A bone wave-whitened and dried in the wind.
”
—William Butler Yeats (1865–1939)