Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“Sang a bone upon the shore;
“A man if I but held him so
When my body was alive
Found all the pleasure that life gave”:
A bone wave-whitened and dried in the wind.”
—William Butler Yeats (1865–1939)
“My Friend is not of some other race or family of men, but flesh of my flesh, bone of my bone. He is my real brother.”
—Henry David Thoreau (1817–1862)
“I wonder, Mr. Bone man, what you’re thinking
of your fury now, gone sour as a sinking whale,
crawling up the alphabet on her own bones.”
—Anne Sexton (1928–1974)