Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“My Friend is not of some other race or family of men, but flesh of my flesh, bone of my bone. He is my real brother.”
—Henry David Thoreau (1817–1862)
“We as women know that there are no disembodied processes; that all history originates in human flesh; that all oppression is inflicted by the body of one against the body of another; that all social change is built on the bone and muscle, and out of the flesh and blood, of human creators.”
—Andrea Dworkin (b. 1946)
“Sang a bone upon the shore;
“A child found all a child can lack,
Whether of pleasure or of rest,
Upon the abundance of my breast”:
A bone wave-whitened and dried in the wind.
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—William Butler Yeats (1865–1939)