Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“Osteopath—One who argues that all human ills are caused by the pressure of hard bone upon soft tissue. The proof of his theory is to be found in the heads of those who believe it.”
—H.L. (Henry Lewis)
“You must be wise, in order to sniff out and weigh these mighty books, and swift in the hunt and brave in the battle; then, by careful reading and frequent reflection, crack open the bone and suck out the substantific marrow.”
—François Rabelais (1494–1553)