Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“I wonder, Mr. Bone man, what you’re thinking
of your fury now, gone sour as a sinking whale,
crawling up the alphabet on her own bones.”
—Anne Sexton (1928–1974)
“You must be wise, in order to sniff out and weigh these mighty books, and swift in the hunt and brave in the battle; then, by careful reading and frequent reflection, crack open the bone and suck out the substantific marrow.”
—François Rabelais (1494–1553)
“Sang a bone upon the shore;
“A child found all a child can lack,
Whether of pleasure or of rest,
Upon the abundance of my breast”:
A bone wave-whitened and dried in the wind.
”
—William Butler Yeats (1865–1939)