Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“Take adultery or theft.
Merely sins.
It is evil who dines on the soul,
stretching out its long bone tongue.
It is evil who tweezers my heart,
picking out its atomic worms.”
—Anne Sexton (1928–1974)
“You must be wise, in order to sniff out and weigh these mighty books, and swift in the hunt and brave in the battle; then, by careful reading and frequent reflection, crack open the bone and suck out the substantific marrow.”
—François Rabelais (1494–1553)
“Fowls in the frith,
Fishes in the flood,
And I must wax wod:
Much sorrow I walk with
For best of bone and blood.”
—Unknown. Fowls in the Frith. . .
Oxford Book of Short Poems, The. P. J. Kavanagh and James Michie, eds. Oxford University Press.