Bone
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.
Read more about this topic: Cannabinoid Receptor, Physiology
Famous quotes containing the word bone:
“People who love soft methods and hate iniquity forget this,—that reform consists in taking a bone from a dog. Philosophy will not do it.”
—John Jay Chapman (1862–1933)
“the bone dry voices of the peepers
as they throb like advertisements.”
—Anne Sexton (1928–1974)
“The wealth and prosperity of the country are only the comeliness of the body, the fullness of the flesh and fat; but the spirit is independent of them; it requires only muscle, bone and nerve for the true exercise of its functions. We cannot lose our liberty, because we cannot cease to think.”
—Humphry, Sir Davy (1778–1829)